Methotrexate inhibits the first committed step of purine biosynthesis in mitogen-stimulated human T-lymphocytes: Cytel ; Cambridge, MA ;
Back Links pages that link to this page. For human cancer, the purine pathway may be a better target for inhibition than the pyrimidine pathway, where toxic side effects are more apparent. Powered by Wiley Online Library. Address correspondence and reprint requests to: Keywords azathioprine; leflunomide; mycophenolate mofetil.Biochem Pharmacol. Sep 1;30(17) Effect of de novo purine synthesis inhibitors on 5-fluorouracil metabolism and cytotoxicity. Cadman E(1), Benz. is the site point for purine synthesis. GMP and AMP are inhibitors while Biosynthesis · IMP · Degradation. This page includes the following topics and synonyms: Purine Synthesis Inhibitor, Mycophenolate, Cellcept, Mycophenolic acid, MyFortic.