To deepen our understanding of this phenomenon, we constructed additional SopfaA5 derivatives. The result might suggest the tandem ACP domains might interact faty each other and an oligomeric quaternary structure might indeed be formed as previously suggested by gel filtration
Dissertation Award in Data are presented as mean values with error bars indicating standard deviation from four independent experiments. Metabolic engineering of Pseudomonas putida for production of docosahexaenoic acid based on a myxobacterial PUFA synthase. Moreover understanding the biosynthesis of complex natural products was frustratingly difficult. Microbial natural products have been an important traditional source of valuable antibiotics and other drugs but interest in them waned in the s when big pharma decided that their discovery was no longer cost-effective and concentrated instead on synthetic chemistry as a source of novel compounds, often with disappointing results. Advances in Chemistry Anal. Содержание Introduction to Polyketide Biosynthesis.other bacterial pfa (polyunsaturated fatty acid) genes, the deduced amino acid sequences are likely to catalyse EPA biosynthesis by a novel polyketide synthesis mechanism. . polyketide synthase (PKS) complexes and fatty acid synthase. Biosynthesis of polyunsaturated fatty acids in lower eukaryotes. by two different pathways: an anaerobic one, by using polyketide synthase related enzymes. Polyunsaturated fatty acids (PUFAs) are essential membrane components in pathways for PUFA synthesis are described that do not require desaturation and.