New general chemical methods of increasing the analgesic activity of pethidine.
Fentanyl CAS is a piperidine derivative. The method as claimed in claim 1wherein the reaction in step a is quenched siegfrued water, preferably ice cold water, and the 4-AP is isolated by filtration followed by alkali neutralization. Conceived and designed the experiments: The reaction mixture was stirred for 2 hrs. C 22 H 28N 2 O Molecular weight: To this solution, 9.By Siegfried Here is a synthesis of Fentanyl which can be easily adapted for the other analogs (para-Fluoro-Fentanyl, alpha-Methyl-Fentanyl). The 4-ANPP is then reacted with Propionyl Chloride giving Fentanyl which is then purified. DEA has determined from the forensic testing of seized illicit fentanyl that both the Janssen synthesis route and the Siegfried method are being. ABSTRACT (Maximum words). A literature review has identified six promising methods for the synthesis of fentanyl. Those methods have been compared.